User self service via radius Cisco ISE

Hi all!!! Please tell me if it is possible to configure the login for self-registration of users through the Radius Cisco ISE server - which is connected to Active Directory. That is, users will themselves enter the self-service through a domain login and password and generate a QR for themselves. Is it possible?

I do not understand this. Maybe due to the fact that I do not exactly what ISE is and how it is involved.
Maybe others also do not understand your question.

So you need to epxlain a bit more.

The privacyIDEA selfservice supports everything you seem to ask for.